منابع مشابه
Gap junctions: Fates worse than death?
The reasons for the molecular heterogeneity of connexin channels in vivo remain unclear. Functional replacement of one connexin gene with another has now revealed unexpected phenotypes and shows that cellular homeostasis depends not simply on cell-cell communication but also on the correct types of connexin.
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valuable information on subjects such as the vitamin A eral human diseases previously thought to be unrelated to gap junctions, including the X-linked form of Charcot-requirements in humans, retinoids and immunity, reti-Marie-Tooth disease (the second most common inher-noid action in the skin and the use of synthetic retinoids ited peripheral neuropathy), multiple types of hearing and synthetic...
متن کاملSynchronized necrotic death of attached hepatocytes mediated via gap junctions
Extensive studies have unveiled the intracellular molecular signaling pathways of cell death. To better understand cell death in tissues, it is important to investigate the influence of neighboring cells on the response to death stimuli. By time-lapse microscopy, we found that cells in couplets (two hepatocytes attached to each other) died independently when stimulated with anti-Fas antibody an...
متن کاملGap junctions mediate bystander cell death in developing retina.
During development of the retina, programmed cell death helps to establish the final size and distribution of various cell classes in distinct layers of the tissue. Here we show that dying cells in the developing ganglion and inner nuclear layers are clustered spatially and that gap junction inhibitors decrease the clustering of dying cells. To confirm the role of gap junctions in cell death, w...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2000
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(00)00689-8